Too many free radicals and reduced antioxidant capacity
Vitamin E, coenzyme Q10, acetyl-L-carnitine, curcumin, resvera- trol, garlic, and broccoli extract work together to increase anti- oxidant capacity in the brain. The B vitamins are not direct anti- oxidants, but they do increase the production of the body’s own antioxidants such as glutathione, coenzyme Q10 and carnitine.
Accumulation of neurotoxins such as heavy metals
The sulfur compounds in garlic and broccoli extract, B vitamins (especially folate, vitamins B2, B6 and B12), choline, betaine, inositol, curcumin and resveratrol stimulate the detoxification of toxins. The antioxidants vitamin E (mixed tocopherols), coen- zyme Q10 and acetyl-L-carnitine limit the harmful effects of neurotoxic substances.
Excessive inflammation
Vitamin E (mixed tocopherols), B vitamins, curcumin, resveratrol, garlic and broccoli extract work together to reduce inflamma- tion in the brain.
References
- Calderón-Ospina CA, Nava-Mesa MO. B Vitamins in the nervous system: Current knowledge of the bio- chemical modes of action and synergies of thiami- ne, pyridoxine, and cobalamin. CNS Neurosci Ther. 2020 Jan;26(1):5-13. doi: 10.1111/cns.13207. Epub 2019 Sep 6. PMID: 31490017; PMCID: PMC6930825.
- Polutchko SK, Glime GNE, Demmig-Adams B. Synergistic Action of Membrane-Bound and Water-Soluble Antioxidants in Neuroprotection. Molecules. 2021 Sep 4;26(17):5385. doi: 10.3390/ molecules26175385. PMID: 34500818; PMCID: PMC8434335.
- Townsend JR, Kirby TO, Sapp PA, et al. Nutrient synergy: definition, evidence, and future directions. Front Nutr. 2023 Oct 12;10:1279925. doi: 10.3389/ fnut.2023.1279925. PMID: 37899823; PMCID: PMC10600480.
