Vários aditivos são neurotóxicos, especialmente para o cérebro em desenvolvimento (Lau K, 2006). Crianças com autismo, que são especialmente sensíveis a substâncias neurotóxicas, podem também reagir mais fortemente a aditivos alimentares.
Um elevado consumo de aditivos alimentares perturba a flora intestinal, danifica a parede intestinal e contribui para a inflamação, tanto no próprio intestino como no resto do corpo. Está, entre outros factores, associado a doenças inflamatórias do intestino, excesso de peso, resistência à insulina, diabetes, assim como problemas de comportamento e hiperactividade em crianças (Raoul P, 2022; Paula Neto HA, 2017; Boris M, 1994; McCann D, 2007; Chazelas E, 2020).
Referências
- Boris M, Mandel FS. Foods and additives are common cause sof the attention deficit hyperactive disorder in children. Ann Allergy. 1994 May;72(5):462-8. PMID: 8179235.
- Buka I, Osornio-Vargas A, Clark B. Foodadditives, essential nutrients and neurodevelopmental behavioural disorders in children: A brief review. Paediatr Child Health. 2011 Aug;16(7):e54-6. doi: 10.1093/pch/16.7.e54. PMID: 22851902; PMCID: PMC3200397.
- Chazelas E, Deschasaux M, Srour B, et al. Food additives: distribution and co-occurrence in 126,000 food products of the French market. Sci Rep. 2020 Mar 4;10(1):3980. doi: 10.1038/ s41598-020-60948-w. PMID: 32132606; PMCID: PMC7055242.
- Lau K, McLean WG, Williams DP, et al. Synergistic interactions between commonly used food additives in a developmental neurotoxicity test. Toxicol Sci. 2006 Mar;90(1):178-87. doi: 10.1093/toxsci/kfj073. Epub 2005 Dec 13. PMID: 16352620.
- McCann D, Barrett A, Cooper A, et al. Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial. Lancet. 2007 Nov 3;370(9598):1560-7. doi: 10.1016/S0140-6736(07)61306-3. Erratum in: Lancet. 2007 Nov 3;370(9598):1542. PMID: 17825405.
- Paula Neto HA, Ausina P, Gomez LS, et al. Effects of Food Additives on Immune Cells As Contributors to Body Weight Gain and Immune-Mediated Metabolic Dysregulation. Front Immunol. 2017 Nov 6;8:1478. doi: 10.3389/fimmu.2017.01478. PMID: 29163542; PMCID: PMC5672138.
- Raoul P, Cintoni M, Palombaro M, et al. Food Additives, a Key Environmental Factor in the Development of IBD through Gut Dysbiosis. Microorganisms. 2022 Jan 13;10(1):167. doi: 10.3390/microorganisms10010167. PMID: 35056616; PMCID: PMC8780106.
